Achievements | Notion

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Morohashi Laboratory @ Tokyo University of Science

諸橋研究室＠東京理科大学

2024

Morohashi, K.,* Ahkami, AH., Coate, JE., and Libault, M. (2024). Editorial: Cellular heterogeneity in plants. Front. Plant Sci. 15:1417460.

2022

Ding, X., Zhang, X., Paez-Valencia, J., McLoughlin, F., Reyes, FC., Morohashi, K., Grotewold, E., Vierstra, RD., Otegui, MS. (2022). Microautophagy mediates vacuolar delivery of storage proteins in maize aleurone cells. Front. Plant Sci. 13:833612.

2021

Negishi, K., Morohashi, K.* (2021). Comprehensive transcriptional analysis reveals gene-specific transcriptional variations in a seed plant, Arabidopsis thaliana. The International Conference on Agents and Artificial Intelligence, (ICAART) 2021: 585-590. (*corresponding author)

2020

Kurumisawa, K., Ishizuna, K., Matsuoka, J.-I., Ogawa, T., Morohashi, K., and Aono, T. (2020). Intercellular and intracellular colonization of Azorhizobium caulinodans in Arabidopsis thaliana under nitrogen deficient conditions, Soil Science and Plant Nutrition 67:71-79.
Umeyama, M§., Hirose, J§., and Morohashi, K.* (2020). UMEPPI: An ultrasensitive detection method for protein– protein interaction. MicroPubl. Biol. 10.17912/micropub.biology.000309. (§undergraduate student).
Umeyama, M§., and Morohashi, K* (2020). Quantitative insight into the combinatorial interactions within MYBBHLH-WD complex in Arabidopsis thaliana. MicroPubl. Biol. 10.17912/micropub.biology.000293. (§undergraduate student)
Okamoto, S., Negishi, K., Toyama, Y., Ushijima, T., and Morohashi, K.* (2020). Leaf trichome distribution pattern in Arabidopsis reveals gene expression variation associated with environmental adaptation. Plants 9:909.

2019

Ishihara, H., Sugimoto, K., Tarr, P.T., Temman, H., Kadokura, S., Inui, Y., Sakamoto, T., Sasaki, T., Aida, M., Suzuki, T., Inagaki, S., Morohashi, K., Seki, M., Kakutani, T., Meyerowitz, E.M., Matsunaga, S. (2019). Primed histone demethylation regulates shoot regenerative competency. Nat Commun. 10:1786.
Arai, H., Yanagiura, K., Toyama, Y., Morohashi, K*. (2019). Genome-wide analysis of MpBHLH12, a IIIf basic helix-loop-helix transcription factor of Marchantia polymorpha. J Plant Res. 132:197-209. (* corresponding author)
Morohashi, K*., Russinova, E. (2019). Towards a next step of the research of regulatory networks in plant growth and development. J Plant Res. 132:155-157. (* corresponding author)
Jones, M.A., Morohashi, K., Grotewold, E., Harmer, S.L. (2019). Arabidopsis JMJD5/JMJ30 acts independently of LUX ARRHYTHMO within the plant circadian clock to enable temperature compensation. Front. Plant Sci. 10:57.

2018

Ilias, I.A., Negishi, K., Yasue, K., Jomura, N., Morohashi, K., Baharum, S.N., Goh, H.H. (2018). Transcriptome-wide effects of expansin gene manipulation in etiolated Arabidopsis seedling. J Plant Res. 132:159-172.
Shibata,M., Breuer, B., Kawamura, A., Clark N.M., Rymen, B., Braidwood, L., Morohashi, K, Busch, W., Benfey, P.N., Sozzani, R., and Sugimoto, K. (2018). GTL1 and DF1 regulate root hair growth through transcriptional repression of ROOT HAIR DEFECTIVE 6-LIKE 4 in Arabidopsis. Development 145:dev159707.

2017

Siarot L, Toyazaki H, Hidaka M, Kurumisawa K, Hirakawa T, Morohashi K, Aono T. A novel regulatory pathway for K+ uptake in the legume symbiont Azorhizobium caulinodans in which TrkJ represses the kdpFABC operon at high extracellular K+ concentrations. (2017). Appl Environ Microbiol 83(19). pii: e01197-17.
Matsuoka JI, Ishizuna F, Kurumisawa K, Morohashi K, Ogawa T, Hidaka M, Saito K, Ezawa T, Aono T. Stringent expression control of pathogenic R-body production in legume symbiont Azorhizobium caulinodans. (2017). MBio. 8(4). pii: e00715-17.
Dhillon T, Morohashi K, Stockinger EJ. CBF2A-CBF4B genomic region copy numbers alongside the circadian clock play key regulatory mechanisms driving expression of FR-H2 CBFs. (2017). Plant Mol Biol. 94(3):333-347.
Iwase, A., Harashima, H., Ikeuchi, M. Rymen, B., Ohnuma, M., Komaki, S., Morohashi, K., Kurata, T., Nakata, M., Ohme-Takagi, M., Grotewold, E., and Sugimoto K. (2017). WIND1 promotes shoot regeneration through transcriptional activation of ESR1 in Arabidopsis. Plant Cell 29(1):54-69.
Yang, F., Li, W., Jiang, N., Yu, H., Morohashi, K., Ouma, Z.W., Morales-Mantill, D.E., Cano, F.A.G., Mukundi, E., Prad, L.D., Velazquez, R.A., Valentin, J., Mejía-Guerra, M.K., Gary, J., Doseff, A.I., Grotewold, E. (2016). A maize gene regulatory network for phenolic metabolism. Mol. Plant 10(3):498-515.

2015

Ikeda, K., Kamisuki, S., Uetake, S., Mizusawa, A., Ota, N., Sasaki, T., Tsukuda, S., Kusayanagi, T., Takakusagi, Y., Morohashi, K., Yamori, T., Dan, S., Shiina, I., Sugawara, F. (2015). Ridaifen G, tamoxifen analog, is a potent anticancer drug working through a combinatorial association with multiple cellular factors. Bioorg Med. Chem. 23(18):6118-24.

2014

Chung, D*, Barker, B.M., Carey, C.C. (*co-first author), Merriman, B., Werner, E.R., Lechner, B.E., Dhingra, S., Cheng, C., Xu, W., Blosser, S.J., Morohashi, K., Mazurie, A., Mitchell, T.K., Haas, H., Aaron P., Mitchell, T., and Cramer, R.A. (2014). ChIP-seq and in vivo transcriptome analyses of the Aspergillus fumigatus SREBP SrbA reveals new insights into fungal hypoxia adaptation and virulence. PLoS Pathogen (Accepted).
Zhiponova, M.K*., Morohashi, K*., (*co-first author) Vanhoutte, I., Machemer-Noonan, K., Revalska, M., Van Montagu, M., Grotewold, and E., Russinova, E. (2014). HLH/bHLH transcription factor network represses cell elongation in Arabidopsis via an apparently incoherent feed-forward loop. Proc. Natl. Acad. Sci. USA 111:2824-2829.
Eveland, A.L., Goldshmidt, A., Pautler, M., Morohashi, K., Liseron-Monfils, C., Lewis, M.W., Kumari, S., Hiraga, S., Yang, F., Unger-Wallace, E., Olson, A., Hake, S., Vollbrecht, E., Grotewold, E., Ware, D*., and Jackson, D*. (2014). Regulatory modules controlling maize inflorescence architecture. Genome Res. 24:431-43.

2013

Arango, D*., Morohashi, K*., (*co-first author) Yilmaz, A., Kuramochi, K., Parihar, A., Brahimaj, B., Grotewold, E., and Doseff, A.I. (2013). Molecular basis for the action of a dietary flavonoid revealed by the comprehensive identification of apigenin human targets. Proc. Natl. Acad. Sci. USA 110:E2153-62.

2012

Breuer, C., Morohashi, K., Kawamura, A., Takahashi, N., Ishida, T., Umeda, M., Grotewold, E., and Sugimoto, K. (2012). Transcriptional repression of the APC/C activator CCS52A1 contributes to the active termination of cell growth. EMBO J. 31:4488-4501.
Sharma, M., Chai, C., Morohashi, K., Grotewold, E., Snook, M.E., and Chopra, S. (2012). Expression of flavonoid 3'-hydroxylase is controlled by P1 the regulator of 3-deoxyflavonoid biosynthesis in maize. BMC Plant Biology 12:196.
Morohashi, K., Casas, M.I., Falcone Ferreyra, L., Mej√≠a-Guerra, M.K., Pourcel, L., Yilmaz, A., Feller, A., Carvalho, B., Emilianid, J., Rodriguez, E., Pellegrinet, S., McMullen, M., Casati, P., and Grotewold, E. (2012). A genome-wide regulatory framework identifies maize Pericarp Color1 (P1) controlled genes. Plant Cell 24: 2745-2764.
Bolduc, N., Yilmaz, A., Mejia-Guerra, M.K., Morohashi, K., O‚ÄôConnor, D., Grotewold, E., and Hake, S. (2012). Unraveling the KNOTTED1 regulatory network in maize meristems. Genes & Dev. 26: 1685-1690. [F1000 recommendation] Mejia-Guerra, M.K., Pomeranz, M., Morohashi, K., and Grotewold, E. (2012). From plant gene regulatory grids to network dynamics. Biochim Biophys Acta. 1819: 454-65.

2011

Takami, M., Takakusagi, Y., Kuramochi, K., Tsukuda, S., Aoki, S., Morohashi, K., Ohta, K., Kobayashi, S., Sakaguchi, K., and Sugawara, F. (2011). A screening of a library of T7 phage-displayed peptide identifies E2F-4 as an etoposide-binding protein. Molecules. 16: 4278-94.
Morohashi, K*., Sahara, H., Watashi, K*., (*co-first author) Iwabata, K., Sunoki, T., Kuramochi, K., Takakusagi, K., Miyashita, H., Sato, N., Tanabe, A., Shimotohno, K., Kobayashi, S., Sakaguchi, K., and Sugawara, F. (2011). Cyclosporin A associated helicase-like protein facilitates the association of Hepatitis C Virus RNA polymerase with its cellular cyclophilin B. PLoS ONE 6(4): e18285.

Before 2010

Xie, Z., Lee, E. -K., Lucas, J.R., Morohashi, K., Li, D., Murray, J.A.H., Sack, F.D., and Grotewold, E. (2010). Regulation of stomatal lineage cell proliferation by the Arabidopsis MYB FOUR LIPS via direct targeting of core cell cycle genes. Plant Cell 22: 2306-21.
Ferreyra, M. L, Rius, S., Emiliani, J., Pourcel, L., Feller, A, Morohashi, K., Casati, P, and Grotewold, E. (2010). Cloning and characterization of a UV-B inducible maize flavonol synthase. Plant J. 62: 77-91.
Morohashi, K., Xie, Z., and Grotewold, E. (2009). Gene-specific and genome-wide ChIP approaches to study plant transcriptional networks. Methods in Molecular Biology. In Plant Systems Biology. Belostotsky, D. (ed) Humana Press , NJ. 553: 3-12.
Morohashi, K and Grotewold, E. (2009). A Systems Approach Reveals Regulatory Circuitry for Arabidopsis Trichome Initiation by the GL3 and GL1 Selectors. PLoS Genetics 5(2): e1000396.
Zhao, M., Morohashi, K., Hatlestad, G., Grotewold, E., and Lloyd, A. (2008). The TTG1-bHLH-MYB complex controls trichome cell fate and patterning through direct targeting of regulatory loci. Development. 135: 1991-1999.
Aoki, S., Morohashi, K., Sunoki, T., Kuramochi, K., Kobayashi, S., and Sugawara, F. (2007). Screening of paclitaxel-binding molecules from a library of random peptides dsplayed on T7 phage particles using paclitaxel-photoimmobilized resin. Bioconjugate Chem. 18: 1981-1986.
Morohashi, K*., Zhao, M*., Yang, M* (co-first author)., Nguyen, B., Read, B., Lloyd, A., Lamb, R., and Grotewold, E. (2007). Participation of the Arabidopsis basic helix-loop-helix factor GL3 in trichome initiation regulatory events. Plant Physiol. 145: 736-746.
Hernandez*, J. M., Feller*, A., Morohashi, K* (co-first author)., Frame, K., and Grotewold, E. (2007). The basic helix-loop-helix domain of maize R links transcriptional regulation and histone modifications by recruitment of an EMSY-related factor. Proc. Natl. Acad. Sci. USA. 104: 17222-17227.
Asada, M., Bayarmaa, G.-A., Morohashi, K., and Hiratsuka, K. (2007). Expression and subcellular localization of pre-rRNA processing factor homologues in higher plants. Plant Biotechnol. 24: 301-306.
Saotome, A., Kimura, S., Mori, Y., Uchiyama, Y., Morohashi, K., and Sakaguchi, K. (2006). Characterization of four RecQ homologues from rice (Oryza sativa L. cv. Nipponbare). Biochem. Biophys. Res. Commun. 345: 1283-1291.
Morohashi, K*., Arai, T* (co-first author)., Saito, S., Watanabe, M., Sakaguchi, K., and Sugawara, F. (2006). A high-throughput phage display screening method using a combination of real-time PCR and affinity chromatography. Comb. Chem. High Throughput Screen. 9: 55-61.
Takakusagi, Y., Ohta, K., Kuramochi, K., Morohashi, K., Kobayashi, S., Sakaguchi, K., and Sugawara, F. (2005). Synthesis of a biotinylated camptothecin derivative and determination of the binding sequence by T7 phage display technology. Bioorg. Med. Chem. Let. 15: 4846-4849.
Morohashi, K., Yoshino, A., Yoshimori, A., Saito, S., Tanuma, S., Sakaguchi, K., and Sugawara, F. (2005). Identification of a drug target motif: an anti-tumor drug NK109 interacts with a PNxxxxP. Biochem. Pharm. 70: 37-46.
Morohashi, K., Minami, M., Takase, H., Hotta, Y., and Hiratsuka, K. (2003). Isolation and characterization of a novel GRAS gene that regulates meiosis-associated gene expression. J. Biol. Chem. 278: 20865-20873.
Bayarmaa, G.-A., Morohashi, K., Takase, H., and Hiratsuka, K. (2003). Identification of novel microsporogenesis-associated genes encoding proteins with a nuclear localization signal. Plant Biotechnol. 20: 137-143.
Morohashi, K., Takase, H., Hotta, Y., and Hiratsuka, K. (2000). Large-scale sequencing of meiosis-associated genes from a cDNA library of lily microsporocytes. Plant Biotechnol. 17: 131-135.
Mizushina, Y., Yagi, H., Tanaka, N., Kurosawa, T., Seto, H., Katsumi, K., Onoue, M., Ishida, H., Iseki, A., Nara, T., Morohashi, K., Horie, T., Onomura, Y., Narusawa, M., Aoyagi, N., Takami, K., Yamaoka, M., Inoue, Y., Matsukage, A., Yoshida, S., and Sakaguchi, K. (1996). Screening of inhibitor of eukaryotic DNA polymerases produced by microorganisms. J. Antibiot. (Tokyo). 49: 491-492.